应用电子线对瘢痕疙瘩术后治疗效果临床—去除剖腹产与隆乳手术造成之瘢痕疙瘩

研究緣起:自古以來愛美是人的天性,臺灣在美容醫學上的發展尤其在近二三十年來不斷的突飛猛進,由於經濟能力的提升和人們對外在的要求越來越高,因此病人接受整形外科手術的機率不斷提高。相對的,也有一些手術後的後遺症造成病友與醫師之間的一些衝突,瘢痕疙瘩的發生就是其中一個很重要的問題。一直以來瘢痕疙瘩都是醫師與患者共同的一個問題,輕者影響美觀,重者影響肢體功能,雖然目前治療的策略已經比以前進步很多,也有一些藥物或生物製劑加上手術方式的進步,使瘢痕疙瘩發生的機率已經減少很多,但是到目前為止,仍然沒有一種可以完全根絕瘢痕疙瘩發生的策略,一旦瘢痕疙瘩發生後,病人目前大約能夠選擇皮射、再次進行手術除疤等方式消除瘢痕疙瘩,但是卻沒有一種方式能夠確保瘢痕疙瘩不再復發。因此如何在切除瘢痕疙瘩後防止其復發是整形外科醫師一個很重要的課題。目的:1906年De Beurman首次發表了利用放射線來治療瘢痕疙瘩,隨後Coan於1961年對瘢痕疙瘩手術後使用X射線來預防瘢痕疙瘩再復發,兩者都發表有正向療效的文獻。隨後由於病友的需求,醫師經過不斷的研究試驗,瘢痕疙瘩術後放射治療有許多的文獻報導,也都是正面的證明電子線能有效預防瘢痕疙瘩復發。但接受放射治療最好的時機和每次最佳放射劑量並沒有一個比較規範的治療建議,本實驗的目的就是以總量相同的照射劑量,分割成不同的劑量分次照射,以病友的臨床結果觀察後做統計及浅析浅析,希望能找出較佳的治療時機及劑量。策略:2006.9-2007.9年選取臺灣地區瘢痕疙瘩病友66例,所有患者均接受手術切除全部瘢痕疙瘩,按整形外科減張無創傷縫合,在術後24小時內,分成3組實驗組。總劑量均為18GY,A組單次劑量1GY,連續18次,1次/日,共計18日;B組單次劑量3GY,連續6次,1次/日,共計6日;C組單次劑量6GY,連續3次,1次/日,共計3日;分別為A、B、C三組。結果:在顯效及改善皆屬於有效的定義下,A組有效率為36.36%,B組有效率為81.82%,C組有效率為72.73%。三組兩兩比較,A、B,A、C兩組差別有顯著意義 B、C組差別無統計學意義。但在嚴格的訂定顯效方為有效的情形下,A組有效率為18.18%,B組有效率為54.55%,C組有效率為45.45%。B組明顯為3組中效果最好的一組。結論:術後早期放療是治療瘢痕疙瘩的一種有效的策略,在總量18GY前提下,分割劑量為3GY時,行每日一次效果最佳。

【Abstract】wWw.shuoshilunwen.com Background:With the pursuit of beauty being an integral part of human nature since time immemorial, Taiwan’s aesthetical medicine development that has undergone leaps and bounds in the past two to three decades, coupled with a rising GDP and a higher desire for physical appearance, has ailed opportunities for would-be patients to seek aesthetical surgical procedures. Consequently, some post-surgical side effects he come to mar the relationship between the physician and the patient, with scars and blemishes being one of the common, yet critical problems. With scars and blemishes long been a problem between patients and doctors, in less severe cases it affects a patient’s topical aesthetics, and in severe cases it could affect a patient’s mobility of limbs. And in spite that the present treatment methods he progressed greatly than before, yet so far there has not been any method that can completely eradicate scars or blemishes from occurring, and once scars and blemishes occur, presently a patient has the options of either undergo hypodermis injection, or undergo subsequent surgery to remove scars and blemishes, yet there is no method capable of ensuring that scars and blemishes will not occur. In light of which, how best to prevent the recurrence after scar, blemish removal has emerged to become a critical issue among aesthetics surgical physicians.Objective: Following De Beurman’s unveiling scar and blemish treatment using radiation in 1906, soon after Coan had adopted X-ray on scar, blemish surgery to prevent the recurrence of scars and blemishes in 1961, with both regarded as valuable archival revelations offering positive treatment yield. Thereafter, in response to the patient’s demands, physicians in general he kept up research and experimentations, with many archival reports publishing on post-scar/blemish procedure radiation treatment, which he all provided positive prove that electron beams can effective prevent the recurrence of scars and blemishes. Yet there has not been a more systematic treatment recommendation on the best timing to receiving the radiation treatment, or the proper dosage in each treatment session. The objective of the experiment has been to observe the select patient samples’clinical results, based on administering the identical total amount of radiation dosage but divided into different dosages and treatment sessions, in an attempt to locate an optical timing and dosage of treatment.Methods: During the period spanning from Sept. 2006 to Sept. 2007, with a total of sixty-six scar and blemish patient cases in Taiwan chosen, and all patients undergoing complete scar, blemish removal procedure, and reduced tension, trauma-free stitching, the patient samples are divided into three experiment groups within 24 hours following the procedure. With the total dosage set to 18GY, Group A is given a single dosage of 1G& for a 18 consecutive sessions of once per day, totaling 18 days; Group B is given a single dosage of 3GY for a consecutive 6 sessions of once per day, totaling six days; Group C is given a single dosage of 6GY for a consecutive three session of once per day, totaling 3 days.Results: Under the definition that both apparent yield and improvement are deemed effective, Group A is found with an effective ratio of 36.36%, Group B with an effective ratio of 81.82%, and Group C with an effective ratio of 72.73%. To compare the three groups in pairs, groups A/B ad A/C are found with significantly apparent deviations, while groups B/C are found without any statistical significance. Under a strict definition that only apparent yield is deemed effective, Group A has an effective ratio of 18.18%, Group B has an effective ratio of 54.55%, Group C has an effective ratio of 45.45%. Group B is ominously the best group among the three.Conclusion:With early post-surgical procedure treatment being an effective method to treat scars and blemishes, under a requisite total dosage of 18GY, the treatment of dividing the dosage into 3GY and administered daily is found with the most optimal results.

【关键词】 瘢痕疙瘩;手術治療;放射治療;
【Key words】 Keloid;Operative therapy;Electron beam;

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瘢痕疙瘩术后电子线治疗70例回顾性

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