芎冰滴丸药学

【Abstract】wWw.shuoshilunwen.com Chuanxiong,as a genuine staple herb of Sichuan,has a function of activating Qi and blood circulation,expelling Wind and alleviating pain.It’s clinical using lies mainly in treatment of disharmony of menses,amenorrhea and dyenorrhea,pain in abdomen,punctuating pain between the chest and hypochondrium,galls caused by tumbling,headache,torpid pain caused by rheumati.Under the guidance of basic theory of TCM,in combination of modern pharmacology and clinical experimental results,in this research,we chose naphtha of Chuanxiong matched with bormeol as study object,made them transdermal delivery system to improve the suffers’ acclimatization,reduce ill effections,enrich clinic dosage forms to serve people better, so as to realize the comprehensive utility of Chnanxiong.Aiming at the above problems,first,content of naphtha and ligustilide was chosen as indexes,single factor experiment as experimental method to compare various extraction technics of naphtha in Chuanxiong,and water-steaming extraction was determined;second,technical condition was optimized,and it is proved that under the best condition,extraction ratio of naphtha can be around 0.45%,while the content of ligustilide can be around 61%.Research into quality standard of naphtha in Chuanxiong was carried out,and the consequences showed that compounds such as hydroxybenzenes,carbonies,lactones, unsaturations were found in the naphtha,the relative density of which is about 0.9909,refraction ratio about 1.5128,pH value about 4.26,acid number about 27.6,saponification unmber about 223,content of ligustilide about 61%;leing-sample observation was adopted to study the stability of naphtha in Chuanxiong,and the results signified that the quality and clinical curative effect can be conserved under the circumstance of -20℃,oiding light,obturation.The pain threshold test and hot plate test were used to work over the matching dosage of Chuanxiong naphtha and borneol,and the outcome showed that the adults can take respectively 40mg and 13mg each day.We used the method of single fractor experiment and orthogonal design to optimize the prescription,finding out that the best prescription should be:the proportion of host herb(including starch and Vit E those occupying the proportion of 10%and 0.1%of the naphtha in Chuanxiong)and auxiliary material is 1:2;and the auxiliary material is the mixing of PEO4000 and PEG6000(1:1).The ligustilide pill’s quality was estimated synthetically by the study of quality standard,which proved that XiongBing-pill is stable and controllable.It was found that through determination of dissolution rate,comparing withβ-CD tablets of the content of naphtha and,XiongBing-pill is better than the other two ones concerning in dissolubility.The research verified that XiongBing-pill’s procedure is stable and the quality is controllable.Comparing with the other oral solid preparation,XiongBing-pill he fast reaction.